Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net	Kernel	Elements	Min	Max	Average	Standard_Deviation
biological_process	ct	46	0.0	0.703	0.069	0.161
biological_process	el	46	0.066	0.96	0.598	0.253
biological_process	ka	46	0.0	0.643	0.07	0.164
biological_process	rf	46	0.0	0.703	0.069	0.161
cellular_component	ct	1	0.006	0.006	0.006	0.0
cellular_component	el	1	0.006	0.006	0.006	0.0
cellular_component	ka	1	0.006	0.006	0.006	0.0
cellular_component	rf	1	0.006	0.006	0.006	0.0
disease	ct	23	0.002	0.853	0.13	0.234
disease	el	23	0.005	0.795	0.195	0.245
disease	ka	23	0.001	0.86	0.134	0.246
disease	rf	23	0.002	0.853	0.13	0.234
pathway	ct	30	0.001	0.994	0.073	0.181
pathway	el	30	0.001	0.208	0.03	0.053
pathway	ka	30	0.001	0.848	0.16	0.256
pathway	rf	30	0.001	0.176	0.033	0.049
phenotype	ct	11	0.001	0.465	0.068	0.136
phenotype	el	11	0.046	0.44	0.195	0.109
phenotype	ka	11	0.001	0.795	0.117	0.235
phenotype	rf	11	0.001	0.466	0.068	0.136
protein_interaction	ct	73	0.0	0.741	0.038	0.125
protein_interaction	el	73	0.0	0.779	0.039	0.132
protein_interaction	ka	73	0.0	0.969	0.184	0.294
protein_interaction	rf	73	0.0	0.74	0.037	0.124

Table 2. Backup position values for every kernel after integration

Integration	Kernel	Elements	Max	Average	Standard_Deviation
integration_mean_by_presence	ct	73	0.637	0.036	0.101
integration_mean_by_presence	el	73	0.882	0.052	0.158
integration_mean_by_presence	ka	73	0.94	0.064	0.175
integration_mean_by_presence	rf	73	0.688	0.035	0.1
mean	ct	73	0.691	0.037	0.106
mean	el	73	0.882	0.047	0.129
mean	ka	73	0.927	0.061	0.169
mean	rf	73	0.899	0.045	0.124

CDF plots of non integrated kernels

CDF plots of integrated kernels