Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 46 0.0 0.703 0.069 0.161
biological_process el 46 0.066 0.96 0.598 0.253
biological_process ka 46 0.0 0.643 0.07 0.164
biological_process rf 46 0.0 0.703 0.069 0.161
cellular_component ct 1 0.006 0.006 0.006 0.0
cellular_component el 1 0.006 0.006 0.006 0.0
cellular_component ka 1 0.006 0.006 0.006 0.0
cellular_component rf 1 0.006 0.006 0.006 0.0
disease ct 23 0.002 0.853 0.13 0.234
disease el 23 0.005 0.795 0.195 0.245
disease ka 23 0.001 0.86 0.134 0.246
disease rf 23 0.002 0.853 0.13 0.234
pathway ct 30 0.001 0.994 0.073 0.181
pathway el 30 0.001 0.208 0.03 0.053
pathway ka 30 0.001 0.848 0.16 0.256
pathway rf 30 0.001 0.176 0.033 0.049
phenotype ct 11 0.001 0.465 0.068 0.136
phenotype el 11 0.046 0.44 0.195 0.109
phenotype ka 11 0.001 0.795 0.117 0.235
phenotype rf 11 0.001 0.466 0.068 0.136
protein_interaction ct 73 0.0 0.741 0.038 0.125
protein_interaction el 73 0.0 0.779 0.039 0.132
protein_interaction ka 73 0.0 0.969 0.184 0.294
protein_interaction rf 73 0.0 0.74 0.037 0.124

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 0.637 0.036 0.101
integration_mean_by_presence el 73 0.0 0.882 0.052 0.158
integration_mean_by_presence ka 73 0.0 0.94 0.064 0.175
integration_mean_by_presence rf 73 0.0 0.688 0.035 0.1
mean ct 73 0.0 0.691 0.037 0.106
mean el 73 0.0 0.882 0.047 0.129
mean ka 73 0.0 0.927 0.061 0.169
mean rf 73 0.0 0.899 0.045 0.124

CDF plots of non integrated kernels

CDF plots of integrated kernels